Molecular Formula | C12H9Cl2D9N2O |
Molar Mass | 286.248 |
Melting Point | 112-115°C |
Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
Stability | Store in Freezer |
Refractive Index | 1.577 |
Risk Codes | R25 - Toxic if swallowed R22 - Harmful if swallowed |
Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN2811 6.1/PG 3 |
HS Code | 28459000 |
application | clinically, it is mainly used to prevent and treat bronchospasm, human and animal bronchial asthma and asthmatic chronic bronchitis, and it can also play a good role in the treatment of nerve, bone, urinary, reproductive, respiratory and other system diseases, so it is used as an antiasthmatic medicine in medicine. |
pharmacological action | clenbuterol is a selective β2 receptor agonist, which binds to β2 receptors widely distributed on respiratory cell membranes, resulting in changes in receptor configuration, activation of adenylate cyclase, catalyzing the conversion of intracellular ATP into cAMP, promoting the decrease of free calcium concentration in the cytoplasm, opening of potassium channels, and causing smooth muscle relaxation. Clinically, it is mainly used as a bronchial antispasmodic drug, which has good effects on bronchial asthma and chronic bronchitis accompanied by reversible airway obstruction. It has strong pharmacological effects. The effect of relaxing bronchial smooth muscle is 100 times that of salbutamol, a commonly used antispasmodic and antiasthmatic drug. After oral administration, it is quickly absorbed in the gastrointestinal tract, and the absorption is complete, almost up to 100%. The oral therapeutic dose for adults is only 30 μg/d ~ 40 μg/d. The oral effect is 170 times that of terbutaline, and the effect on heart rate and blood pressure is not obvious. In addition to relaxing bronchial smooth muscle, clenbuterol also excites β2 receptors in other parts of the body, such as vascular smooth muscle, skeletal muscle and uterus. clenbuterol acts on skeletal muscle β2 receptor, causing the concentration of cAMP and lactic acid in muscle to increase rapidly, and the concentration of muscle glycogen to decrease, accelerating the synthesis of muscle protein. Long-term continuous use can increase muscle volume and weight. Eating pigs can increase the lean meat rate of pork. However, it must be seriously pointed out that this is not the pharmacological effect of clenbuterol at all, because if it is to really have the effect of "lean meat", the dosage used is dozens of times the therapeutic dose of antispasmodic and antiasthmatic effect, which can cause pigs and consumers to become ill and produce serious symptoms. |